DIEA

N,N-Diisopropylethylamine, also known as Hünig′s base, is a sterically hindered amine which imparts to its non-nucleophilic base characteristics. Thus, the lone pair of electrons resides on the nitrogen atom can only react with small electrophiles such as protons. Besides used as a synthon itself, DIEA is a very useful organic reagent widely used in many reactions in the synthesis of pharmaceutical anesthetics, pesticide, herbicides, and peptide synthesis.
(1) As the hindered base in amide coupling reactions between a carboxylic acid (typically activated, for example, as an acid chloride, as illustrated below) and a nucleophilic amine.
(2) As a selective reagent in the alkylation of secondary amines to tertiary amines by alkyl halides.
(3) As a proton scavenger.
(4) In transition metal catalyzed cross-coupling reactions such as the Heck coupling and the Sonogashira coupling.
In addition, DIEA also bears similar properties of triethylamine but has much lower solubility in water which makes it very easily recovered in commercial processes.

Advantages:		Applications:
	High quality		Synthon for pharmaceuticals, pesticide, herbicides, and other complex organic compounds.
	Very competitive price		Condensation agent
	Annual capacity: 500MTS		Catalyst
			Proton scavenger

CAS: 7087-68-5

Appearance: Colorless liquid

Purity: 99.00% min.